Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus (HR-HPV) in Young Men (2008)

This article, published in the Journal of Infectious Diseases, investigates the association between male circumcision and the prevalence of high-risk human papillomavirus virus (HR-HPV) among young men.

Data was collected from uncircumcised men ages 18-24 years old in Africa.  Study participants were randomized into two groups, circumcised (MC) and not circumcised (control group), and they were required to attend follow-up visits.  The men were offered circumcision services if they were randomized into the MC group.  Circumcision status and sexual behaviors information were recorded at each visit.  At the 21-month follow-up visit, a urethral swab was obtained and tested for HR-HPV.

The researchers found that the prevalence of HR-HPV was 14.8% for men in the MC group and 22.3% for men in the uncircumcised group.  This was the first research study showing the reduction of urethral HR-HPV after male circumcision.  These results also explained why women with circumcised partners are at a lower risk of cervical cancer than other women.

Citation:

Auvert, B., Sobngwi-Tambekou, J., Cutler, E., Nieuwoudt, M., Lissouba, N., Puren, A. and D. Taljaard. Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus (HR-HPV) in Young Men. 2008. Journal of Infectious Diseases. 199(1):14-19.

Link to “Effect of Male Circumcision on the Prevalence of High-Risk Human Papillomavirus (HR-HPV) in Young Men”

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